Post Translational Modification of Proteins & related Biological Implications

• Inorganic Chemistry
• Bio-inorganic & Bio-organic Chemistry
• Biology For Chemists
• Natural Products & Protecting Agents
• Pesticides Chemistry

14 Years (after PhD) experience in teaching as well as in research

• Project Fellow-Department of Chemistry, University of Delhi funded by Danish International Development Agency (DANIDA), Denmark.
• Senior Research Fellowship-Department of Chemistry, University of Delhi, funded by University of Southern Denmark (Nucleic Acid Chemistry, NAC).
• Senior Research Fellowship-Council of Scientific & Industrial Research (CSIR, New Delhi).
• Research Associate-Council of Scientific & Industrial Research (CSIR, New Delhi).
• Young Scientist-Department of Science and Technology (SERB-DST, New Delhi).
• Appreciation Letter- Received from Elsevier Science, Netherlands.
• Travel Grant: Received from International Society for the Study of Xenobiotics (ISSX) for attending International Conference in Istanbul, Turkey.
•  First “Hon’ble Founder Chancellor Best Teacher Award”  from SRM University Delhi-NCR, Sonepat, Haryana

1. Published (Year wise):

1. Smriti Gupta, Ajit Kumar,  Vishwajeet Rohil, ADAM33: “Role and pathogenesis study in COPD in Delhi NCR Population”  International Journal of Biological & Medical Research 10 (1),  2019,  6623 – 6630 [IF=5.51]

2. Rajesh Sinha, Pooja Singh, Neeraj k Saini, Ajit Kumar et al., “Methyl-accepting chemotaxis like Rv3499c (Mce4A) protein in Mycobacterium tuberculosis H37Rv mediates cholesterol dependent survival.” Tuberculosis 109(2018): 52-60. [IF=2.790]

3. Rini joshi, Shvetambri arora, Ajit kumar et al., the competence of 7,8-diacetoxy-4-methylcoumarinand other polyphenolic   acetates in mitigating the oxidative stress and their role in angiogenesis. Current topics in medicinal chemistry 2015 doi: 10.2174/1568026615666141209162446[IF=3.442]
4. Rini Joshi, Ajit Kumar et al., Calreticulin transacetylase mediated upregulation of thioredoxin by 7,8-diacetoxy-4-methylcoumarin enhances the antioxidant potential and the expression of vascular endothelial growth factor in peripheral blood mono nuclear cells. Chemico Biol. Interact. 266 (2014) 327-336. [IF=3.407].
5. Ajit Kumar et al., Comparative specificities of Calreticulin Transacetylase to O-acetyl, N-acetyl and S-acetyl derivative of 4-methylcoumarins and their inhibitory effect on AFB₁-induced genotoxicity in vitro and in vivo. Food Chem. Toxicol. 52 (2013)216-224 [IF=3.775].
6. Ajit Kumar et al., Calreticulin Transacetylase mediated activation of nitric oxide synthase in human platelet by acetyl group donor compounds. Nitric Oxide 26 (2012)9-19     [IF=3.371].
7. Ajit Kumar et al., Prevention of benzene-induced genotoxicity in bone marrow and lung cells: superiority of polyphenolic acetates to polyphenols Arch. Toxicol. 85 (2011)1141-1150   [IF=5.741].
8. Sushma Manral, Sumati Bhatia, Rajesh Sinha, Ajit Kumar et al., Normalization of deranged signal transduction in lymphocytes of COPD patients by the novel calcium channel blocker H-DHPM. Biochimie 93 (2011) 1146-1156 [IF=3.362].
9. Anil S. Baghel, Rashmi Tandon, Garima Gupta, Ajit Kumar et al., Characterization of protein acyltransferase function of recombinant purified GlnA1 from Mycobacterium tuberculosis: A moon lighting property. Microbiol. Res. 166 (2011)662-672 [IF=3.701].
10. Ranju Kumari, Seema Bansal, Garima Gupta, Shvetambri Arora, Ajit Kumar, et al., Calreticulibn transacetylase: Genesis, mechanism of action and biological applications.  Biochimie 92 (2010) 1173-1179 [IF=3.362].
11. Usha Singh, Ajit Kumar et al., Calreticulin transacetylase catalyzed modification of the TNF-? mediated pathway in the human peripheral blood mononuclear cells by polyphenolic acetates, Chem. Biol. Interact. 185 (2010) 263-270 [IF=3.407].
12. Ajit Kumar et al., Specificities of Acetoxy derivatives of Coumarins, Biscoumarins, Chromones, Flavones, Isoflavones and Xanthones for Acetoxy Drug: Protein Transacetylase. European Journal of Medicinal Chemistry 42 (2007)447-455 [IF=4.833].
13. Sarvesh Kumar, Brajendra K. Singh, Anil K. Pandey, Ajit Kumar et al., A chromone analog inhibits TNF-? induced expression of cell adhesion molecules on human endothelial cells via blocking NF-kB activation. Bioorganic & Medicinal Chemistry. 15 (2007) 2952-2962 [IF=2.802].
14. Ajit Kumar et al., Ellagic acid peracetate is superior to ellagic acid in the prevention of genotoxicity due to aflatoxin B₁ in bone marrow and lung cells J. Pharmacy and pharmacology.1 (2007) 81-86 [IF=2.390].
15. Pulkit Khurana, Ranju Kumari, Parag Vohra, Ajit Kumar et al., Acetoxy drug: Protein transacetylase catalyzed activation of human platelet nitric oxide synthase by polyphenolic Peracetates. Bioorganic & Medicinal Chemistry 14 (2006) 575-583 [IF=2.802].
16. Ajit Kumar et al., Mechanism of biochemical action of substituted 4-methylcoumarins. Part 11: Comparison of the specificities of acetoxy derivatives of 4-methylcoumarin and 4-phenylcoumarin to acetoxycoumarins: protein transacetylase. Bioorganic & Medicinal Chemistry. 13 (2005) 4300-4305 [IF=2.802].
17. Yogesh K. Tyagi, Ajit Kumar et al.,  Synthesis of novel amino and acetyl amino-4- methylcoumarins and evaluation of their antioxidant activity. European Journal of Medicinal Chemistry 40 (2005) 413–420 [IF=4.833].
18. Babita Madan, Ishwar Singh, Ajit Kumar et al., Xanthones as Inhibitors of Microsomal Lipid Peroxidation and TNF-? Induced Endothelial ICAM-1 Expression on Human Umbilical Vein Cells (HUVECs). Bioorganic & Medicinal Chemistry 10 (2002) 3431-3436. [IF=2.802].