Drug Screening in Cancer Biology, Neurodegenerative Disorder and Diabetes Regenerative Medicine, Bone marrow transplantation.

Postdoctoral Training in the field of Cancer Biology and Diabetes in Boston Biomedical Research Institute and St Caritas Medical Center, Tufts University, Boston, USA.

Undergraduate Courses (B. Tech): Introduction to Biological Science, Genomics in Medicine, rDNA Technology, Protein Engineering

Postgraduate Courses (M. Tech, M.Sc and PhD): Advanced Genetic Engineering, Functional Genomics and Proteomics, Molecular Therapeutics, Molecular Biology, Cancer Biology, Highthroughput, Population Genetics, Transgenic Engineering.

RECIPIENT OF DST Fast track Scheme for Young Scientist—Approved on “Identification and characterization of anti-cancerous and anti-angiogenic biomolecules for colon cancer” Grant started on June 2013-June 2016; Amount-Rs.27 Lakhs.

CSIR Scientific Pool Officer (Under Scientist Pool Scheme)-Project approved on “Screening and Investigation of biomolecules for therapy of Diabetes via cell culture method. Grant started on July 2016-2019; Rs 20 Lakh

• Total research and teaching experience: 22 years

  Reviewer of prestigious journal including American Diabetes Association Journals, Wiley , Elsevier Journal etc; Invited Speaker=10

  Professional scientific writing degree: University of Pennsylvania, USA

1994                Distinction in Science (Holy Cross School, Bokaro Steel City, India)

1997                Distinction in General Science, Bokaro Mahilla College, Bokaro Steel City, India

1997                Lions Club speaker on Women Empowerment, Bokaro Steel City, India

2000                First prize in M.Sc Seminar presentation on Gene Therapy, BHU, Varanasi, India

2001                RET-JRF (Research entrance test- Junior Research Fellowship), Varanasi, India

2001                ASRB-Lecturerships, qualification for lecturership, New Delhi, India

2001                CSIR-JRF), New Delhi, India

2001                ICMR-JRF, New Delhi, India

2002                DFG BAT IIa/2 (Deutche Forchung Geminschaft) Fellowship, Frankfurt, Germany

2004-08           NIH postdoctoral fellowship (Availed), USA

2004-07           Biomedical Writing Certification from University of Pennsylvania, USA

2007                Centenary Research associate (RA) fellowship from (IISc), Bangalore (Not availed)

2010                Life Membership (L-495) of Society for Biotechnologists, (INDIA)

2010                ISSCR Membership (#27110)

2011                Funding and Research Appreciation Certificate from VIT, Vellore, TN, India

2010                Life Membership of IACR

2011                Finalist of DBT Innovative young Biotechnology Award (DBT-IYBA), Govt of India

2012                Life member, Society for Neurochemistry India

2012                SERB Young scientist (Fast track scheme), DST, Govt of India

2016                CSIR Senior Research Associateship (Under  Scientist Pool Scheme), Govt of India

2017                Elsevier Outstanding Reviewer certification from TIV

2017                Commendable Research Award from Delhi Technological University, Delhi, India

2019                Commendable Research Award from Delhi Technological University, Delhi, India

2020                Commendable Research Award from Delhi Technological University, Delhi, India

2021                Commendable Research Award from Delhi Technological University, Delhi, India

2022                Commendable Research Award from Delhi Technological University, Delhi, India

Publications: 75+; Conference/proceedings and invited talks: 100+; Total citations: 2989; h-index: 27; i-10: 42; cumulative impact factor of all publications: 300+ (approx.); No. of more than 10 impact factor papers: 11; Corresponding author paper: 11

Google Scholar: https://scholar.google.co.in/citations?user=0zIYDMkAAAAJ&hl=en

Linkedin: https://in.linkedin.com/in/rashmi-ambasta-229086a0

ResearchGate: https://www.researchgate.net/profile/Rashmi-Ambasta/2

Pubmed: https://pubmed.ncbi.nlm.nih.gov/?term=Ambasta+RK

Orcid ID: https://orcid.org/0000-0002-8874-7752

•Kumari S, Gupta R, Ambasta RK*, Kumar P. Emerging trends in post translational modification: shedding light on glioblastoma multiforme; BBA Reviews on Cancer Biochim Biophys Acta Rev; Accepted; 2023 October. (Impact factor: 11.2; * Corresponding author)

•New era of artificial intelligence and machine learning-based detection, diagnosis, and therapeutics in Parkinson's disease. Ageing Res Rev. 2023 Jul 8;90:102013. doi: 10.1016/j.arr.2023.102013. Epub ahead of print. PMID: 37429545 (Impact factor: 13.1)

•Kumari S, Gupta R, Ambasta RK, Kumar P. Multiple therapeutic approaches of glioblastoma multiforme: From terminal to therapy. Biochim Biophys Acta Rev Cancer. 2023 Jul;1878(4):188913. doi: 10.1016/j.bbcan.2023.188913. Epub 2023 May 12. PMID: 37182666 (Impact factor: 11.2)

•Gupta R, Kumari S, Tripathi R, Ambasta RK, Kumar P. Unwinding the modalities of necrosome activation and necroptosis machinery in neurological diseases. Ageing Res Rev. 2023 Apr;86:101855. doi: 10.1016/j.arr.2023.101855. Epub 2023 Jan 18. PMID: 36681250 (Impact factor: 13.1)

•Chakraborty P, Dey A, Gopalakrishnan AV, Swati K, Ojha S, Prakash A, Kumar D, Ambasta RK, Jha NK, Jha SK, Dewanjee S. Glutamatergic neurotransmission: A potential pharmacotherapeutic target for the treatment of cognitive disorders. Ageing Res Rev. 2023 Mar;85:101838. doi: 10.1016/j.arr.2022.101838. Epub 2023 Jan 5. PMID: 36610558 (Impact factor: 13.1)

•S Kumari, S Sharma, D Advani, A Khosla, P Kumar, RK Ambasta Unboxing the molecular modalities of mutagens in cancer; Environmental Science and Pollution Research, 2021 Oct 5:1-49 (IF:4.2) [*: Corresponding author]

•Sharma A, Kumar P, Ambasta RK. *; Cancer Fighting SiRNA-RRM2 loaded nanorobots; Pharm Nanotechnol. 2020 [*: Corresponding author]

•Sharan S, Kumar P, Ambasta RK*.; Discovery of Novel Compounds Targeting; DJ-1 as Neuroprotectants for Parkinson's Disease by Virtual Screening and in Silico Method.; Curr Comput Aided Drug Des. 2020 Apr 17. (IF=1.2) [*: Corresponding author]

•Kohli H, Kumar P, Ambasta RK. In silico designing of putative peptides for targeting pathological protein Htt in Huntington's disease. Heliyon. 2021 Feb 12;7(2):e06088. doi: 10.1016/j.heliyon.2021.e06088. PMID: 33659724; PMCID: PMC7890153. (IF:3) [*: Corresponding author]

•Kumari S, Advani D, Sharma S, Ambasta RK, Kumar P. Combinatorial therapy in tumor microenvironment: Where do we stand? Biochim Biophys Acta Rev Cancer. 2021 Jul 2;1876(2):188585. doi: 10.1016/j.bbcan.2021.188585. Epub ahead of print. PMID: 34224836.(Impact factor::11.2)

•Gupta R, Sahu M, Srivastava D, Tiwari S, Ambasta RK, Kumar P. Post-translational modifications: Regulators of neurodegenerative proteinopathies. Ageing Res Rev. 2021 Jul;68:101336. doi: 10.1016/j.arr.2021.101336. Epub 2021 Mar 26. PMID: 33775891. .( Impact factor: 13.1)

•Ambasta RK*, Adeshara K, Yadav S, Kumar P. VEGF/CDK2 are involved in diabetic organ regeneration. Biochem Biophys Res Commun. 2020 Sep 3;529(4):1094-1100. doi: 10.1016/j.bbrc.2020.07.014. Epub 2020 Jul 31. PMID: 32819570 (IF=2.9) [*: Corresponding author]

•Kumar D, Ambasta RK, Kumar P; Ubiquitin biology in neurodegenerative disorders: From impairment to therapeutic strategies; Ageing Res Rev. 2020 Aug;61:101078. (Impact factor: 13.1)

•Advani D, Gupta R, Tripathi R, Sharma S, Ambasta RK, Kumar P. Protective role of anticancer drugs in neurodegenerative disorders: A drug repurposing approach. Neurochem Int. 2020 Nov;140:104841. doi: 10.1016/j.neuint.2020.104841. Epub 2020 Aug 24. PMID: 32853752. .(IF=3.9)

•Ambasta RK, Gupta R, Kumar D, Bhattacharya S, Sarkar A, Kumar P.; Can luteolin be a therapeutic molecule for both colon cancer and diabetes?; Brief Funct Genomics. 2018 Nov 21. doi: 10.1093/bfgp/ely036. [Epub ahead of print] PMID:30462152; [*: Corresponding author] IF: 3.7

•Chauhan S, Manivasagam G, Kumar P, Ambasta RK.; Cellular Toxicity of Mesoporous Silica Nanoparticle in SHSY5Y and BM-MNCs Cell.; Pharm Nanotechnol. 2018 Oct 31.. [Epub ahead of print] PMID:30381088; [*: Corresponding author]

•Jha NK, Jha SK, Sharma R, Kumar D, Ambasta RK, Kumar P.; Hypoxia-Induced Signaling Activation in Neurodegenerative Diseases: Targets for New Therapeutic Strategies.; J Alzheimers Dis. 2018;62(1):15-38. doi: 10.3233/JAD-170589.; PMID:29439330 IF:3.9

•Rashmi K. Ambasta*, Harleen Kohli, Pravir Kumar; Multiple Therapeutic effect of EPC regulated by drugs in Diabetes and Diabetes related disorder. JTM; Aug 31;15(1):185. doi: 10.1186/s12967-017-1280-y. Impact factor: 8.44; [*: Corresponding author]; Citation=22

•Sharma R, Kumar D, Jha NK, Jha SK, Ambasta RK, Kumar P.; Re-expression of cell cycle markers in aged neurons and muscles: Whether cells should divide or die?; Biochim Biophys Acta. 2017 Sep 14 Jan;1863(1):324-336 ; Review. Impact factor: 5

•Saurabh Kumar Jha, Niraj Kumar Jha, Dhiraj Kumar, Renu Sharma, Abhishek Srivastava, Rashmi K. Ambasta, Pravir Kumar* (2017), “Stress-induced synaptic dysfunction and neurotransmitter release in Alzheimer's disease: Can neurotransmitter and Neuromodulator be  potential therapeutic targets? 57(4):1017-1039, (invited manuscript; Special issue: Neurotransmitters and Alzheimer’s disease) Article in press Journal of Alzheimer’s Disease Impact factor: 3.93

•Saurabh Kumar Jha, Niraj Kumar Jha, Dhiraj Kumar, Rashmi K. Ambasta, Pravir Kumar* (2017), Linking mitochondrial dysfunction, metabolic syndrome and stress signaling in Neurodegeneration, Biochimica et Biophysica Acta, BBA Molecular Basis of disease; May;1863(5):1132-1146 (invited manuscript; Special issue: Oxidative Stress and Mitochondrial Quality in Diabetes/Obesity and Critical Illness Spectrum of Diseases) Article in press; Impact factor: 5.158

•Saurabh Kumar Jha, Niraj Kumar Jha, Pravir Kumar and Rashmi K Ambasta (2017),MolecularChaperones and Ubiquitin Proteasome System in Tumor Biogenesis: An Overview, Journal of Cell Biology and Cell Metabolism, 3: 010

•Rashmi K. Ambasta*, Saurabh Kumar Jha, Dhiraj Kumar, Renu Sharma, Niraj Kumar Jha, and Pravir Kumar(2015); Comparative study of anti-angiogenic activities of luteolin, lectin and lupeol biomolecules; 2015 Sep 18;13:307.Journal of Translational Medicine Impact factor: 8.44 [*: Corresponding author]; Citation=17

•Niraj Kumar Jha, Saurabh Kumar Jha, Dhiraj Kumar, Noopur Kejariwal, Renu Sharma, Rashmi K Ambasta and Pravir Kumar (2015), Impact of IDE and Neprilysin in Alzheimer's Disease biology: Characterization of putative coagnates for therapeutic applications. Accepted Journal of Alzheimer’s Disease (IF=4.17) 14th July 2015

•Dhiraj Kumar, Sakshi Sharma, Sagar Verma, Pravir Kumar and Rashmi Kumar Ambasta (2015), Role Of wnt-p53-Nox Signaling Pathway In Cancer Development And Progression, British Journal of Medicine and Medical Research (ISSN: 2231-0614), Vol. 8(8)

•Arivarasan A., Soni Krishna, Shivangi Yadav, Harshit Rajesh Shah, Pravir kumar, Rashmi Kumar Ambasta* (2014), Synergy of bone marrow transplantation and curcumin ensue protective effect at early onset of diabetes in mice, Accepted 23 July, Journal of Diabetes, (Wiley) Impact factor 3.2 [Corresponding author]

•Pravir Kumar, Niraj Kumar Jha, Saurabh Kumar Jha, Karunya Ramani and Rashmi K Ambasta (2014), Tau phosphorylation, molecular chaperones, Ubiquitin E3 ligase: clinical relevance in Alzheimer’s disease, Journal of Alzheimer’s Disease (Accepted June 7, 2014), Impact factor: 4.17

•Sonia Angeline, Aditi Sarkar, Kushi Anand, Rashmi K Ambasta and Pravir Kumar (2013), Sesamol and naringenin reverse the effect of rotenone induced PD rat model, Neuroscience, Volume 254, 19 December 2013, Pages 379-394; Impact factor: 3.48

•Pravir Kumar, Rohan Kar, P.B. Sharma and Rashmi K. Ambasta (2013), Collaborative action of Cell cycle, molecular chaperones and Ubiquitin proteasome system in Neurooncology, Journal of Protein and Proteomics, 4(1), pp 35-43; Impact factor: 0.46

•Pravir Kumar, Irshad Gandhi, P.B. Sharma and Rashmi K. Ambasta (2013), Why our heart is not prone to cancer?, American Journal of Research Communication, 1 (7), 143-151

•Rashmi K. Ambasta*; A miracle cell: Stem Cell: Friend or Foe? ; American Journal of Research communication; 2013; (* - Corresponding author)

•Aditi Sarkar, Sonia Angeline, Kushi Anand, Rashmi K Ambasta and Pravir Kumar, (2012), Neuroprotective effect of flavanoids in hypobaric hypoxia in murine model, Brain Research; Oct 24;1481:59-70; Impact factor: 2.78

•Sonia Angeline, Priya Chatterjee, Kushi Anand, Rashmi K Ambasta and Pravir Kumar, (2012) “Rotenone induced Parkinsonism elicit the behavioral impairment along with differential expression of Parkin, heat shock proteins and caspase in rat, Neuroscience, 220; 291–301* - Corresponding author) Impact factor: 3.48; Citation=59

•Kushi Anand, Aditi Sarkar, Anup Kumar, Rashmi K Ambasta and Pravir Kumar (2012) Combinatorial anti-tumor effect of Naringenin and Curcumin elicit angio-inhibitory activity in vivo Nutrition and Cancer, Vol. 64, issue 5;Impact factor: 2.76

•Arivarasan, Gaurav Rana, Archita Sharma, Manish Kumar, Karishma Jhang, Arundhati Chakraborty, Pravir Kumar, Rashmi K Ambasta (2012), “Clinical management of lipid profile, renal and liver function versus HbA1c profile in diabetes affected patients of Vellore, Tamil Nadu, India”, African Journal of Pharmacy and pharmacology 6 (40), 2832-2836 Impact factor: 1.3); (* -Corresponding author)

•Kushi Anand, Pallavi Asthana, Anup Kumar, Rashmi K Ambasta and Pravir Kumar (2012), Quercetin mediated reduction of angiogenic markers and chaperones in DLA induced solid tumours; Asian Pacific J Cancer Prev, 12, 2829-2835; Impact factor: 2.2

•Pravir Kumar, Kaveri Pradhan, R. Karunya, Rashmi K Ambasta and Henry W. Querfurth (2012), “Cross functional E3 ligase CHIP and Parkin in neurological disorders, Journal of Neurochemistry; Feb;120(3):350-70Nov 20. Impact factor: 4.34; Citation=58

•Rashmi K. Ambasta, Archita Sharma, Pravir Kumar (2011), “Nanoparticle mediated targeting of VEGFR and cancer stem cells for cancer therapy” Vascular Cell 2011, 3:26 (BMC journal). Impact factor: 2.2 (* -Corresponding author); Citation=45

•Harshit Shah, Arivarsan A, Pravir Kumar and Rashmi K Ambasta, (2011)“ Protective effect of bone marrow transplantation in organ damage due to diabetes” African Journal of Pharmacy and pharmacology, Vol.5 (23), pp2605-2612, December; Impact factor: 0.839; (* -Corresponding author)

•Rashmi K. Ambasta, Xingbin Ai, Charles P. Emerson Jr., “QSulf1 function requires asparagine-linked glycosylation.” Journal of Biological Chemistry (2007) Nov 23; 282(47): 34492-9. Epub 2007 Sep 12. (IF: 5.4; Citation-24 times).

•Pravir Kumar, Rashmi K. Ambasta, Vimal Veereshwarayya, Kenneth M Rosen, Cam Patterson, Ken S Kosik, Hamid Band, Ruben Mestril, and Henry W Querfurth “CHIP and HSPs interact with β-APP in a proteasome-dependent manner and influence Aβ metabolism”. Human Molecular Genetics, (2007) Apr 1; 16(7): 848-64. (IF: 8.03; Citation-139)

•Rashmi K. Ambasta, Judith G Schreiber, Mariano Janiszewski, Rudi Busse, Ralf P.Brandes, “Noxa1 is a central component of the smooth muscle NADPH oxidase in mice. Free Radical biology of Medicine (2006) July 15;41(2):193-201 Commentary on this paper by Lassegue B, Griendling KK Nox is playing with a full deck in vascular smooth muscle, a commentary on "Noxa1 is a central component of the smooth muscle NADPH oxidase in mice". Free Radic Biol Med. 2006 Jul 15; 41(2):185-7. (IF: 5.8; Citation- 99 times)

•Rashmi K. Ambasta, Pravir Kumar, Harald H.H.W. Schmidt, Rudi Busse and Ralf P. Brandes  “Direct interaction of the novel Nox proteins with p22phox for the formation of a functionally active NADPH oxidase”, Journal of Biological Chemistry’ (2004); 279: 45935-45941 (IF: 5.4; Citation- 658 times).

https://publons.com/researcher/1677552/rashmi-ambasta/

American Diabetes Association Journal Reviewer (Diabetes Care; IF=13); Cell Physiology and Biochemistry(IF=5); Cancer Biology and Medicine(IF=5.6); The FEBS Journal(IF=4.2) Wiley; Toxicology In Vitro(IF=3); Elsevier; Plos One(If=3); Oncotarget(IF=5); MAJ(IF=1); IEEE Transaction on Nanotechnology; Expert review of Neurotherapeutics; IEEE Access; American Journal of  Research Communication; Journal of Current Research in Science; International Journal of Advanced Biotechnology and Bioinformatics

COLLABORATORS:

J.W Goethe University, Frankfurt am Main and University of Heidelberg, Germany

Alabama State University, USA, NIH/NCI, Maryland, USA

IIT Delhi, Chennai, VIT Vellore, India

ACTREC Mumbai, India

IISC(Bangalore), India

SPECIAL TRAINING FOR RESEARCH:

Professional Online Writing Degree from University of Pennsylvania, USA

Confocal Live Cell Imaging  from MIT, Boston, USA

Post Doc Chalk Talk and scientific committee member for organizing scientific Seminar, USA

Two Dimensional Gel Electrophoresis from Prof Hermann Schagger, Germany

Proteomics and Imaging Training from Prof Ralf P. Brandes, Germany

Invited Speaker:

Rashmi K. Ambasta (2013), International conference of Recent advances in molecular mechanism of neurological disorders, February, 2013, All India Institute of Medical Sciences (AIIMS), New Delhi, India

Rashmi K. Ambasta (2013), National conference on “Emerging trends and Challenges in the Basic and Translational Research in Biochemistry February 4-5, 2013, Banaras Hindu University, Varanasi, India.

Rashmi K. Ambasta (2013), UGC Orientation Program “Cancer Biology” Jamia Millia Islamia, Delhi

Rashmi K. Ambasta(2013), Asian Congress of Biotechnology, IIT Delhi “Sulfatase: a promising new molecule for cancer therapy”

Rashmi K. Ambasta(2013), Bioworld, IIT Delhi, Computer assisted nano-drug design for cancer therapy.

Rashmi K. Ambasta (May’ 2014)” Therapeutic role of biomolecules in cancer” JMI, Delhi; Refresher course for 4^th three weeks Refresher Course in Basic Sciences (Interdisciplinary) faculty development program conducted by UGC-Academic Staff College of Jamia Millia Islamia University, New Delhi; Speaker: Dr. Rashmi K. Ambasta.

Rashmi K. Ambasta^$; Molecular profile analysis of screened anti-angiogenic biomolecules for colon cancer Therapy; Oct 2015 International conference for stem cell and cancer; ICSCC, Pune, India.

Rashmi K. Ambasta^$ (2015); Molecular target profile analysis of luteolin and lupeol for colon cancer Therapy; Oct 2015; OMICS 6^th world congress on Biotechnology, New Delhi, India.

Rashmi K. Ambasta^$ (2015);; Screening of Anti-Cancer Drug: a nano targeting challenge for the next Generation; Nov 2015; Global Cancer Summit, Bangalore, India

Rashmi K. Ambasta (2015);; Advances in Computational Neurochemistry and Neurobiology, SNCI-ACNN December’2015 North Eastern Hill University, Shillong, Meghalaya, India

Rashmi K. Ambasta (2023) National Symposium on Advances in deciphering cellular and Molecular Mechanism on modern Neroscience; Jamia Hamdard University; SNCI, Delhi  Local Chapter, JHU, Delhi

Rashmi K. Ambasta (2023) DST STUTI Training Program, Jamia Hamdard University, JHU, Delhi